Article

Therapeutic knockdown of MLKL reduces diet-induced obesity and improves insulin signalling in mature adipocytes

2026-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Obesity affects one in three adults and is complicated by adipose inflammation, lipotoxicity and cell death. We previously identified RIPK1 as a genetic determinant of human obesity risk and adipose inflammation. Because RIPK1 is the apical kinase in the necroptosis pathway upstream of RIPK3 and the executioner protein MLKL, and emerging evidence links MLKL to lipid metabolism, MLKL has surfaced...

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Literature Corpus work: 4de9a38f-9fd2-57d1-b083-f5f8a9b2681e
DOI: 10.64898/2026.04.17.719119

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