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Article

Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.

International journal of molecular sciences - 20 Feb 2021

Tardelli Matteo, Bruschi Francesca V, Fuchs Claudia D, Claudel Thierry, Auer Nicole, Kunczer Victoria, Ronda Onne A H O, Verkade Henkjan J, Stojakovic Tatjana, Scharnagl Hubert, Trauner Michael

Abstract excerpt

Altered lipid metabolic pathways including hydrolysis of triglycerides are key players in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Whether adiponutrin (patatin-like phospholipase domain containing protein-3-PNPLA3) and monoacylglycerol lipase (MGL) synergistically contribute to disease progression remains unclear. We generated double knockout (DKO) mice lacking both Mgl and Pnpla3; DKO mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33672787
DOI: 10.3390/ijms22042126
PMCID: PMC7924608

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Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.PMID 33672787Read ↗

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