Article

RIP3 and MLKL regulate Hepatic ER stress in alcohol-associated liver disease and pharmacological ER stress models: insights beyond necroptosis

2025-09-25

Abstract excerpt

<h4>Background and Aim</h4> Endoplasmic reticulum (ER) stress is an important contributor to liver disease progression, including alcohol-associated liver disease (ALD). While receptor-interacting protein kinase-3 (RIP3) and mixed lineage kinase domain-like pseudokinase (MLKL) are known for their roles in necroptosis, emerging evidence highlights their non-canonical functions in metabolic regulation and cellular...

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Literature Corpus work: 12bba618-3506-5d79-99d1-4b703c18b57b
DOI: 10.1101/2025.09.24.677754

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