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Article

Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis.

NAR cancer - 1 Jun 2026

Tran Thi, Fan Jiayi, Zhao Xiaolan, Green Abby M

Abstract excerpt

The structural maintenance of chromosomes (SMC) 5/6 complex is conserved and essential for mammalian development. SMC5/6 germline variants in cells, model organisms, and patients results in genome instability. However, the consequences of somatic SMC5/6 dysfunction in cancer are unknown. We report a pan-cancer analysis of SMC5/6 variants across three databases in which thousands of tumors across all tissue types...

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Identifiers

PMID: 42181931
DOI: 10.1093/narcan/zcag012
PMCID: PMC13191284

Genes

SMC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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