Article

SAMHD1 promotes oncogene-induced replication stress

2020-07-29

Abstract excerpt

Oncogenes induce DNA replication stress in cancer cells. Although this was established more than a decade ago, we are still unravelling the molecular underpinnings of this phenomenon, which will be critical if we are to exploit this knowledge to improve cancer treatment. A key mediator of oncogene-induced replication stress is the availability of DNA precursors, which will limit ongoing DNA synthesis by cellular r...

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Literature Corpus work: 7d461b6f-8522-5561-8150-ea9db35fe3ba
DOI: 10.1101/2020.07.29.226282

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