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Article

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

PLoS genetics - 1 Jan 2018

Peng Xiao P, Lim Shelly, Li Shibai, Marjavaara Lisette, Chabes Andrei, Zhao Xiaolan

Abstract excerpt

Smc5/6, a member of the conserved SMC family of complexes, is essential for growth in most organisms. Its exact functions in a mitotic cell cycle are controversial, as chronic Smc5/6 loss-of-function alleles produce varying phenotypes. To circumvent this issue, we acutely depleted Smc5/6 in budding yeast and determined the first cell cycle consequences of Smc5/6 removal. We found a striking primary defect in...

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Share to Cell Cycle Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29360860
DOI: 10.1371/journal.pgen.1007129
PMCID: PMC5779651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.PMID 29360860Read ↗

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