Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability.

Nucleic acids research - 1 Dec 2016

Peng Jie, Feng Wenyi

Abstract excerpt

The Smc5/6 complex is implicated in homologous recombination-mediated DNA repair during DNA damage or replication stress. Here, we analysed genome-wide replication dynamics in a hypomorphic budding yeast mutant, smc6-P4 The overall replication dynamics in the smc6 mutant is similar to that in the wild-type cells. However, we captured a difference in the replication profile of an early S phase sample in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to DNA Mismatch Repair
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Fungal

Share to Genomic Instability

Share to Hydroxyurea

Share to Multiprotein Complexes

Share to Ribonuclease H

Source

Open in PubMed Open full text

Identifiers

PMID: 27536003
DOI: 10.1093/nar/gkw720
PMCID: PMC5137426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability.PMID 27536003Read ↗

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.Semantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stressSemantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Abrupt telomere losses and reduced end-resection can explain accelerated senescence of Smc5/6 mutants lacking telomerase.Semantic proximity Read ↗

Replication fork dynamics and the DNA damage response.Semantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.Semantic proximity Read ↗

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.