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Article

Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome.

Cell reports - 22 Sept 2020

Chakraborty Arijita, Jenjaroenpun Piroon, Li Jing, El Hilali Sami, McCulley Andrew, Haarer Brian, Hoffman Elizabeth A, Belak Aimee, Thorland Audrey, Hehnly Heidi, Schildkraut Carl L, Chen Chun-Long, Kuznetsov Vladimir A, Feng Wenyi

Abstract excerpt

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation repressor whose nuclear function is not understood. We investigated the global impact on genome stability due to FMRP loss. Using Break-seq, we map spontaneous and replication stress-induced DNA double-strand breaks (DSBs) in an FXS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32966779
DOI: 10.1016/j.celrep.2020.108179
PMCID: PMC7549430

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