Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.

Abstract excerpt

Meiotic recombination commences with hundreds of programmed DNA breaks; however, the degree to which they are accurately repaired remains poorly understood. We report that meiotic break repair is eightfold more mutagenic for single-base substitutions than was previously understood, leading to de novo mutation in one in four sperm and one in 12 eggs. Its impact on indels and structural variants is even higher,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Breaks, Double-Stranded
• Share to DNA Repair
• Share to Genome, Human