Article

Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis

2025-04-03

Abstract excerpt

Transcription factors (TFs) influencing cell fate can be dysregulated in cancer. FLI1 is crucial for hematopoietic stem/progenitor cell (HSPC) function, with STAG2 regulating FLI1 target accessibility. STAG2 depletion enhances HSPC self-renewal, but its role in leukemic transformation is unclear. We uncovered that STAG2 loss maintains FLI1 target accessibility in murine HSPCs and enhances FLI1 binding in NPM1c leu...

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Identifiers and source

Literature Corpus work: 17e51ee3-4e9e-568f-95f8-4525e367fcb1
DOI: 10.1101/2025.04.01.646632

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