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Article

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

2018-10-13

Abstract excerpt

<h4>SUMMARY</h4> We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating the highest-resolution 3D genome maps to-date for this cancer. Integration of DNA contact maps with chromatin and transcriptional profiles identified specific mechanisms of gene regulation, including individual physical interactions between regulatory regions and...

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Literature Corpus work
93823d77-58ac-5000-8173-a2fe21ca73f7
DOI
10.1101/442277
Open publication

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