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Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma

4 Apr 2019

Abstract excerpt

Glioblastoma is an incurable brain cancer characterized by high genetic and pathological heterogeneity. Here, we mapped active chromatin landscapes with gene expression, whole exomes, copy number profiles, and DNA methylomes across 44 patient-derived glioblastoma stem cells (GSCs), 50 primary tumors, and 10 neural stem cells (NSCs) to identify essential super-enhancer (SE)-associated genes and the core...

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PMID: 30948495
DOI: 10.1084/jem.20190196

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