Article

Structural and functional basis of the universal transcription factor NusG pro-pausing activity in <i>Mycobacterium tuberculosis</i>

2022-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional pauses mediate regulation of RNA biogenesis. DNA-encoded pause signals trigger elemental pausing by stabilizing a half-translocated (RNA-not-DNA) state and by promoting RNAP swiveling that other factors can enhance. The universal transcription factor NusG (Spt5 in eukaryotes and archaea) N-terminal domain (NGN) modulates pausing through contacts to RNAP and DNA. Pro-pausing NusGs...

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Literature Corpus work: 1c00fd34-4388-581c-ba7f-dd28ca257bcd
DOI: 10.1101/2022.10.21.513233

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