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Article

Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2019

Jia Ning, Unciuleac Mihaela C, Xue Chaoyou, Greene Eric C, Patel Dinshaw J, Shuman Stewart

Abstract excerpt

Mycobacterial AdnAB is a heterodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand breaks (DSBs). The AdnA and AdnB subunits are each composed of an N-terminal motor domain and a C-terminal nuclease domain. Here we report cryoelectron microscopy (cryo-EM) structures of AdnAB in three functional states: in the absence of DNA and in complex with forked duplex DNAs before...

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Identifiers

PMID: 31740608
DOI: 10.1073/pnas.1913546116
PMCID: PMC6900545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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