Article
Escherichia coli transcription factor NusG binds to 70S ribosomes.
Molecular microbiology - 1 Jun 2018
Saxena Shivalika, Myka Kamila K, Washburn Robert, Costantino Nina, Court Donald L, Gottesman Max E
Abstract excerpt
Transcription and translation are coupled processes in bacteria. A role of transcription elongation cofactor NusG in coupling has been suggested by in vitro structural studies. NMR revealed association of the NusG carboxy-terminal domain with S10 (NusE), implying a direct role for NusG as a bridge linking RNAP and the lead ribosome. Here we present the first in vitro and in vivo evidence of full-length NusG...
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