Article

Structure of the human RNA Polymerase I Elongation Complex

2021-06-02

Abstract excerpt

<title>Abstract</title> <p>Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal DNA and generates RNA for ribosome synthesis. Pol I accounts for the majority of cellular transcription activity and dysregulation of Pol I transcription leads to cancers and ribosomopathies. Despite extensive structural studies of yeast Pol I, structure of human Pol I remains unsolved. Here, we determined the structures of the h...

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Literature Corpus work: 819ee825-5879-54b5-b1b6-6abb7e134ff7
DOI: 10.21203/rs.3.rs-576610/v1

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