Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.

Nucleic acids research - 10 Nov 2014

Windgassen Tricia A, Mooney Rachel Anne, Nayak Dhananjaya, Palangat Murali, Zhang Jinwei, Landick Robert

Abstract excerpt

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (TH) required for rapid nucleotide addition. The nascent RNA pause hairpin forms in the RNA exit channel and promotes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Nucleotides

Share to Protein Folding

Share to Protein Structure, Tertiary

Share to Protein Unfolding

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25336618
DOI: 10.1093/nar/gku997
PMCID: PMC4227799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.PMID 25336618Read ↗

Modulation of RNA polymerase activity through the trigger loop folding.Semantic proximity Read ↗

Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translationSemantic proximity Read ↗

Allosteric control of RNA polymerase by a site that contacts nascent RNA hairpins.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

Two transcription pause elements underlie a σ70-dependent pause cycle.Semantic proximity Read ↗

Structural perspective on mutations affecting the function of multisubunit RNA polymerases.Semantic proximity Read ↗

Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis.Semantic proximity Read ↗

Activity map of the Escherichia coli RNA polymerase bridge helix.Semantic proximity Read ↗

Structural and functional basis of the universal transcription factor NusG pro-pausing activity in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Mutations in RNA Polymerase Bridge Helix and Switch Regions Affect Active-Site Networks and Transcript-Assisted Hydrolysis.Semantic proximity Read ↗

Interplay between the trigger loop and the F loop during RNA polymerase catalysis.Semantic proximity Read ↗

Conserved functions of the trigger loop and Gre factors in RNA cleavage by bacterial RNA polymerases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.