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Article

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.

Nucleic acids research - 11 Mar 2015

Ma Cong, Mobli Mehdi, Yang Xiao, Keller Andrew N, King Glenn F, Lewis Peter J

Abstract excerpt

Pausing during transcription elongation is a fundamental activity in all kingdoms of life. In bacteria, the essential protein NusA modulates transcriptional pausing, but its mechanism of action has remained enigmatic. By combining structural and functional studies we show that a helical rearrangement induced in NusA upon interaction with RNA polymerase is the key to its modulatory function. This conformational...

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Source

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Identifiers

PMID: 25690895
DOI: 10.1093/nar/gkv108
PMCID: PMC4357713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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