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Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization

2022-07-04

Abstract excerpt

<h4>SUMMARY</h4> Self-assembly of macromolecules into higher-order symmetric structures is fundamental for the regulation of biological processes. Higher-order symmetric structure self-assembly by the gene expression machinery, such as bacterial DNA-dependent RNA polymerase (RNAP), has never been reported before. Here, we show that the stress-response σ B factor from the human pathogen, Mycobacterium tuberculos...

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Literature Corpus work
9d89b9a7-7d25-5fdd-9e16-04c3c90b8c84
DOI
10.1101/2022.07.04.498644
Open publication

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Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerizationDOI 10.1101/2022.07.04.498644
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