Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R-loop-dependent promoter-proximal termination ensures genome stability.

Nature - 1 Sept 2023

Xu Congling, Li Chengyu, Chen Jiwei, Xiong Yan, Qiao Zhibin, Fan Pengyu, Li Conghui, Ma Shuangyu, Liu Jin, Song Aixia, Tao Bolin, Xu Tao, Xu Wei, Chi Yayun, Xue Jingyan, Wang Pu, Ye Dan, Gu Hongzhou, Zhang Peng, Wang Qiong, Xiao Ruijing, Cheng Jingdong, Zheng Hai, Yu Xiaoli, Zhang Zhen, Wu Jiong, Liang Kaiwei, Liu Yan-Jun, Lu Huasong, Chen Fei Xavier

Abstract excerpt

The proper regulation of transcription is essential for maintaining genome integrity and executing other downstream cellular functions1,2. Here we identify a stable association between the genome-stability regulator sensor of single-stranded DNA (SOSS)3 and the transcription regulator Integrator-PP2A (INTAC)4-6. Through SSB1-mediated recognition of single-stranded DNA, SOSS-INTAC stimulates promoter-proximal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genomic Instability

Share to Mitochondrial Proteins

Share to Mutation

Share to Promoter Regions, Genetic

Share to RNA Polymerase II

Source

Open in PubMed Open full text

Identifiers

PMID: 37557913
DOI: 10.1038/s41586-023-06515-5
PMCID: PMC10511320

Genes

NABP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R-loop-dependent promoter-proximal termination ensures genome stability.PMID 37557913Read ↗

INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II ComplexesSemantic proximity Read ↗

Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation <i>in vitro</i>Semantic proximity Read ↗

Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivationSemantic proximity Read ↗

Transcription-Coupled Repair and R-Loop Crosstalk in Genome StabilitySemantic proximity Read ↗

Integrator loss leads to dsRNA formation that triggers the integrated stress response.Semantic proximity Read ↗

A universal regulatory mechanism for prevention of replication restart from RNA:DNA hybridsSemantic proximity Read ↗

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesionsSemantic proximity Read ↗

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instabilitySemantic proximity Read ↗

Transcription directionality is licensed by Integrator at active human promotersSemantic proximity Read ↗

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in <i>Brucella</i>Semantic proximity Read ↗

<i>Bacteroides</i> expand the functional versatility of a universal transcription factor and transcribed DNA to program capsule diversitySemantic proximity Read ↗

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.