Article

The structural basis for RNA slicing by human Argonaute2

2024-08-20

Abstract excerpt

<h4>SUMMARY</h4> Argonaute (AGO) proteins associate with guide RNAs to form complexes that slice transcripts that pair to the guide. This slicing drives post-transcriptional gene-silencing pathways that are essential for many eukaryotes and the basis for new clinical therapies. Despite this importance, structural information on eukaryotic AGOs in a fully paired, slicing-competent conformation—hypothesized to be i...

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Literature Corpus work: 5143df5b-e6d2-576e-b020-3c60acb05a95
DOI: 10.1101/2024.08.19.608718

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