Article

ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex

2019-03-22

Abstract excerpt

Fibroblast Growth Factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress FGF signalling has to decline. Why this signalling dynamic is required has not been determined. Here we show that dephosphorylation of the FGF effector kinase ERK1/2 rapidly increases chromatin a...

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Literature Corpus work: 1bec92ce-adb3-5b24-b877-429b6c191b2f
DOI: 10.1101/586719

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