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Article

Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.

eLife - 24 Sept 2014

McGann James C, Oyer Jon A, Garg Saurabh, Yao Huilan, Liu Jun, Feng Xin, Liao Lujian, Yates John R, Mandel Gail

Abstract excerpt

The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification (H3K4me3). In this study, we test whether this mechanism applies equally to genes that are not required until...

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Source

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Identifiers

PMID: 25250711
DOI: 10.7554/eLife.04235
PMCID: PMC4371837

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.PMID 25250711Read ↗

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Reciprocal actions of REST and a microRNA promote neuronal identity.Semantic proximity Read ↗

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.Semantic proximity Read ↗

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