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Article

An AUTS2-Polycomb complex activates gene expression in the CNS.

Nature - 18 Dec 2014

Gao Zhonghua, Lee Pedro, Stafford James M, von Schimmelmann Melanie, Schaefer Anne, Reinberg Danny

Abstract excerpt

Naturally occurring variations of Polycomb repressive complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, autism susceptibility candidate 2 (AUTS2). Although AUTS2 is often disrupted in patients with neuronal disorders, the mechanism underlying the pathogenesis is unclear. We investigated the role of AUTS2 as part of a previously identified PRC1...

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Identifiers

PMID: 25519132
DOI: 10.1038/nature13921
PMCID: PMC4323097

Genes

AUTS2
PRC1

Provenance

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Related research

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Research trail→

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An AUTS2-Polycomb complex activates gene expression in the CNS.PMID 25519132Read ↗

NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the BrainSemantic proximity Read ↗

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Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neuronsSemantic proximity Read ↗

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targetsSemantic proximity Read ↗

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.Semantic proximity Read ↗

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