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Article

A unique bipartite Polycomb signature regulates stimulus-response transcription during development.

Nature genetics - 1 Mar 2021

Kitazawa Taro, Machlab Dania, Joshi Onkar, Maiorano Nicola, Kohler Hubertus, Ducret Sebastien, Kessler Sandra, Gezelius Henrik, Soneson Charlotte, Papasaikas Panagiotis, López-Bendito Guillermina, Stadler Michael B, Rijli Filippo M

Abstract excerpt

Rapid cellular responses to environmental stimuli are fundamental for development and maturation. Immediate early genes can be transcriptionally induced within minutes in response to a variety of signals. How their induction levels are regulated and their untimely activation by spurious signals prevented during development is poorly understood. We found that in developing sensory neurons, before perinatal...

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Identifiers

PMID: 33603234
DOI: 10.1038/s41588-021-00789-z
PMCID: PMC7610396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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