Article
RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.
Molecular cell - 16 Jun 2016
Wei Chaoliang, Xiao Rui, Chen Liang, Cui Hanwei, Zhou Yu, Xue Yuanchao, Hu Jing, Zhou Bing, Tsutsui Taiki, Qiu Jinsong, Li Hairi, Tang Liling, Fu Xiang-Dong
Abstract excerpt
Increasing evidence suggests that diverse RNA binding proteins (RBPs) interact with regulatory RNAs to regulate transcription. RBFox2 is a well-characterized pre-mRNA splicing regulator, but we now encounter an unexpected paradigm where depletion of this RBP induces widespread increase in nascent RNA production in diverse cell types. Chromatin immunoprecipitation sequencing (ChIP-seq) reveals extensive...
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