Article

Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neurons

2025-11-06

Abstract excerpt

Regulation of gene expression by Polycomb group (PcG) proteins orchestrates neural development and cell-type specification. However, the mechanisms by which neural progenitor cells diversify into the myriad cell types of the human brain remain poorly understood. Here, we investigate the role of Polycomb pro-teins in shaping the single-cell 3D genome, transcriptome, and chromatin binding landscape of the developing...

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Literature Corpus work: d558ba8b-ea8b-5fe5-91b3-98a2351af930
DOI: 10.1101/2025.11.05.686502

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