Article
Transcription factors that convert adult cell identity are differentially polycomb repressed.
PloS one - 1 Jan 2013
Davis Fred P, Eddy Sean R
Abstract excerpt
Transcription factors that can convert adult cells of one type to another are usually discovered empirically by testing factors with a known developmental role in the target cell. Here we show that standard genomic methods (RNA-seq and ChIP-seq) can help identify these factors, as most are more strongly Polycomb repressed in the source cell and more highly expressed in the target cell. This criterion is an...
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