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Crosstalk between EZH2 and BCL6 in regulating chronic myeloid leukaemia (CML) stem cell survival : from epigenomics to novel therapeutic approaches

2019-01-01

Abstract excerpt

Chronic Myeloid Leukaemia (CML) is a haematopoietic stem cell disorder characterised by the presence of the BCR-ABL1 fusion gene, which produces a constitutively active tyrosine kinase responsible for disease progression. Despite the introduction of tyrosine kinase inhibitors (TKIs) to target this overactive tyrosine kinase, the low cure rate and risk of disease recurrence and progression remains a major clinical...

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Literature Corpus work
1ba4806b-9623-5155-bca1-b0a61758aca1
DOI
10.5525/gla.thesis.75174
Open publication

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