EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is an aggressive hematological malignancy characterized by sustained peripheral blood monocytosis and an inherent risk for leukemic blast transformation 1 , 2 . Patients with CMML have between 10–15 mutations per kilobase of coding DNA regions; with majority of these (>90%) involving epigenetic regulator genes ( TET2 60%, ASXL1 40%), splicing machinery ( SRSF2 40%), and cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Chronic Myeloid Leukemia Treatments
• Share to Immune Cell Function and Interaction