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Chronic Myeloid Leukemia Stem Cell Biology

30 Mar 2012

Abstract excerpt

Leukemia progression and relapse is fueled by leukemia stem cells (LSC) that are resistant to current treatments. In the progression of chronic myeloid leukemia (CML), blast crisis progenitors are capable of adopting more primitive but deregulated stem cell features with acquired resistance to targeted therapies. This in turn promotes LSC behavior characterized by aberrant self-renewal, differentiation, and...

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PMID: 22467334
DOI: 10.1007/s11899-012-0121-6

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