Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

12 Mar 2021

Abstract excerpt

Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance development remain to be defined in detail. Here we report that loss-of-function mutations (LOF) in the histone methyltransferase EZH2 have the potential to confer resistance against the chemotherapeutic agent cytarabine. We identify seven distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33712646
DOI: 10.1038/s41598-021-84708-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AMLPMID 33712646Read ↗

The epigenetic role of EZH2 in acute myeloid leukemiaSemantic proximity Read ↗

EZH2 dysregulation: Potential biomarkers predicting prognosis and guiding treatment choice in acute myeloid leukaemia.Semantic proximity Read ↗

Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysisSemantic proximity Read ↗

Precision medicine in AML: overcoming resistance.Semantic proximity Read ↗

The Epigenetic Landscape of Acute Myeloid LeukemiaSemantic proximity Read ↗

IDH2 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.Semantic proximity Read ↗

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.Semantic proximity Read ↗

Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells.Semantic proximity Read ↗

Crosstalk between EZH2 and BCL6 in regulating chronic myeloid leukaemia (CML) stem cell survival : from epigenomics to novel therapeutic approachesSemantic proximity Read ↗

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.Semantic proximity Read ↗

EZH2 mutations and impact on clinical outcome: an analysis in 1,604 patients with newly diagnosed acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.