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Leukemia stem cells: the root of chronic myeloid leukemia

9 Mar 2015

Abstract excerpt

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a chromosome translocation that generates the Bcr-Abl oncogene encoding a constitutive kinase activity. Despite remarkable success in controlling CML at chronic phase by Bcr-Abl tyrosine kinase inhibitors (TKIs), a significant proportion of CML patients treated with TKIs develop drug resistance due to the inability of TKIs to...

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PMID: 25749979
DOI: 10.1007/s13238-015-0143-7

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