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The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisis

2025-11-04

Abstract excerpt

Patients with blast crisis in chronic myeloid leukemia (CML) exhibit an extremely poor prognosis, with median survival of only a few months and limited therapeutic options. Dysregulated transcriptional regulation plays a pivotal role in driving blast crisis progression. In this study, we performed histone modification and transcriptomic high-throughput sequencing on bone marrow cells derived from chronic and blast...

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Literature Corpus work
eb6b6a9d-df46-56dd-b4b5-c70d82ac816c
DOI
10.1101/2025.11.02.686161
Open publication

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The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisisDOI 10.1101/2025.11.02.686161
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