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The epigenetic role of EZH2 in acute myeloid leukemia

6 Dec 2024

Abstract excerpt

Acute myeloid leukemia (AML), a malignant disease of the bone marrow, is characterized by the clonal expansion of myeloid progenitor cells and a block in differentiation. The high heterogeneity of AML significantly impedes the development of effective treatment strategies. Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2 (PRC2), regulates the expression of downstream...

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Histone Deacetylase Inhibitors Research
Acute Myeloid Leukemia Research
Epigenetics and DNA Methylation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39655332
DOI: 10.7717/peerj.18656

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