Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2.

doi:10.1111/j.1440-1746.2010.06447.x

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Article

Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2.

Journal of gastroenterology and hepatology - 1 Jan 2011

Tsang Daisy P F, Cheng Alfred S L

Abstract excerpt

EZH2 is the histone H3 lysine 27 methyltransferase of polycomb-repressive complex 2. It transcriptionally silences cohorts of developmental regulators in stem/progenitors and cancer cells. EZH2 is essential in maintaining stem cell identity by globally repressing differentiation programs. Analogo...

Topics

Animals
Cell Differentiation
DNA Methylation
DNA Modification Methylases
DNA-Binding Proteins
Enhancer of Zeste Homolog 2 Protein
Epigenesis, Genetic
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Genotype
Humans
Neoplasms
Phenotype
Polycomb Repressive Complex 2
Prognosis
Signal Transduction
Transcription Factors

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Identifiers

PMID: 21175789
DOI: 10.1111/j.1440-1746.2010.06447.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21175789-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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