Article
The role of EZH2 in the induction and maintenance of acute myeloid leukaemia
2018-01-01
Abstract excerpt
Epigenetic regulators are commonly mutated in cancer. Activating mutations and overexpression of EZH2 occur in lymphoma and other malignancies, while loss-of-function mutations are found in myeloid malignancies. This thesis is a study of this apparent contradiction, examining the importance of cellular context for Ezh2 loss during the evolution of a single malignancy, Acute Myeloid Leukaemia (AML). This work demon...
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Identifiers and source
- Literature Corpus work
- 07066344-4427-5c4f-935d-e6de0f1922c6
- DOI
- 10.17863/cam.20724