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Chronic Myelogenous Leukemia– Initiating Cells Require Polycomb Group Protein EZH2

14 Sept 2016

Abstract excerpt

Tyrosine kinase inhibitors (TKI) have revolutionized chronic myelogenous leukemia (CML) management. Disease eradication, however, is hampered by innate resistance of leukemia-initiating cells (LIC) to TKI-induced killing, which also provides the basis for subsequent emergence of TKI-resistant mutants. We report that EZH2, the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), is overexpressed in CML LICs...

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PMID: 27630126
DOI: 10.1158/2159-8290.cd-15-1439

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