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Chronic myeloid leukemia stem cells: targeting therapeutic implications

1 Dec 2021

Abstract excerpt

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as confirmed by the success of tyrosine kinase inhibitor (TKI) therapy. Despite advances in the development of more potent tyrosine kinase inhibitors, some mechanisms particularly in terms of CML leukemic stem cell (CML LSC) lead to intrinsic...

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PMID: 34922630
DOI: 10.1186/s13287-021-02659-1

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