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Article

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options

1 Aug 2017

Abstract excerpt

The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms of cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate them, is a well-established avenue pursued in translational cancer medicine. Chronic myeloid leukemia (CML) arises clonally when a hematopoietic stem cell (HSC)...

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PMID: 28778403
DOI: 10.1016/j.semcancer.2017.07.006

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