Article

Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA Repair

2020-01-20

Abstract excerpt

<h4>SUMMARY</h4> The evolutionarily conserved POT1 protein binds single stranded G-rich telomeric DNA and has been implicated in contributing to telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics discovering that the complete absence of POT1 leads to severe telomere maintenance defects that had not been anticipated...

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Literature Corpus work: 1b7b2f6f-8a5a-5c75-9104-867c08cc946b
DOI: 10.1101/2020.01.20.912642

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