Article
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore.
Genes & development - 1 Dec 2020
Pinzaru Alexandra M, Kareh Mike, Lamm Noa, Lazzerini-Denchi Eros, Cesare Anthony J, Sfeir Agnel
Abstract excerpt
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genetic and proteomic approaches based on CRISPR interference and biotin-based proximity labeling, respectively. These...
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