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Article

Structural and functional analysis of the human POT1-TPP1 telomeric complex.

Nature communications - 10 Apr 2017

Rice Cory, Shastrula Prashanth Krishna, Kossenkov Andrew V, Hills Robert, Baird Duncan M, Showe Louise C, Doukov Tzanko, Janicki Susan, Skordalakes Emmanuel

Abstract excerpt

POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the interacting portion of the human telomeric POT1-TPP1 complex and suggest how several of these mutations contribute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28393830
DOI: 10.1038/ncomms14928
PMCID: PMC5394233

Genes

POT1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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