Article
Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nature communications - 10 Apr 2017
Chen Cong, Gu Peili, Wu Jian, Chen Xianyun, Niu Shuangshuang, Sun Hong, Wu Lijie, Li Na, Peng Junhui, Shi Shaohua, Fan Cuiying, Huang Min, Wong Catherine C L, Gong Qingguo, Kumar-Sinha Chandan, Zhang Rongguang, Pusztai Lajos, Rai Rekha, Chang Sandy, Lei Ming
Abstract excerpt
Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension. However, how POT1 interacts with TPP1 remains unknown. Here we present the crystal structure of the C-terminal portion of human POT1 (POT1C) complexed with the POT1-binding motif of TPP1. The structure shows that POT1C contains two domains, a third OB fold and a...
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