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Article

Role of POT1 in Human Cancer

24 Sept 2020

Abstract excerpt

Telomere abnormalities facilitate cancer development by contributing to genomic instability and cellular immortalization. The Protection of Telomeres 1 (POT1) protein is an essential subunit of the shelterin telomere binding complex. It directly binds to single-stranded telomeric DNA, protecting chromosomal ends from an inappropriate DNA damage response, and plays a role in telomere length regulation. Alterations...

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Identifiers

PMID: 32987645
DOI: 10.3390/cancers12102739

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