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Article

POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.

Journal of cellular physiology - 1 Jun 2023

Zade Nikita Harish, Khattar Ekta

Abstract excerpt

The protection of telomere protein (POT1) is a telomere-binding protein and is an essential component of the six-membered shelterin complex, which is associated with the telomeres. POT1 directly binds to the 3' single-stranded telomeric overhang and prevents the activation of DNA damage response at telomeres thus preventing the telomere-telomere fusions and genomic instability. POT1 also plays a pivotal role in...

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Share to DNA Repair Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37183325
DOI: 10.1002/jcp.31034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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