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Article

Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.

Science (New York, N.Y.) - 18 Aug 2023

Tesmer Valerie M, Brenner Kirsten A, Nandakumar Jayakrishnan

Abstract excerpt

Protection of telomeres 1 (POT1) is the 3' single-stranded overhang-binding telomeric protein that prevents an ataxia telangiectasia and Rad3-related (ATR) DNA damage response (DDR) at chromosome ends. What precludes the DDR machinery from accessing the telomeric double-stranded-single-stranded junction is unknown. We demonstrate that human POT1 binds this junction by recognizing the phosphorylated 5' end of the...

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Identifiers

PMID: 37590346
DOI: 10.1126/science.adi2436
PMCID: PMC10666826

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Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.PMID 37590346Read ↗

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNASemantic proximity Read ↗

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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protectionSemantic proximity Read ↗

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endSemantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA RepairSemantic proximity Read ↗

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.Semantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.Semantic proximity Read ↗

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