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Article

POT1-TPP1 telomere length regulation and disease

1 Jan 2020

Abstract excerpt

Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primarily by the shelterin and CST complexes. POT1-TPP1, a subunit of shelterin, binds the telomeric overhang, suppresses ATR-dependent DNA damage response, and recruits...

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Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence
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Identifiers

PMID: 32774788
DOI: 10.1016/j.csbj.2020.06.040

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