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Article

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.

The EMBO journal - 1 Dec 2020

Glousker Galina, Briod Anna-Sophia, Quadroni Manfredo, Lingner Joachim

Abstract excerpt

The evolutionarily conserved POT1 protein binds single-stranded G-rich telomeric DNA and has been implicated in contributing to telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics, discovering that a complete absence of POT1 leads to severe telomere maintenance defects that had not been anticipated from previous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33073402
DOI: 10.15252/embj.2020104500
PMCID: PMC7705456

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