Article

Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation

2021-08-17

Abstract excerpt

<h4>SUMMARY</h4> Translating ribosomes unwind mRNA secondary structures by three basepairs each elongation cycle. Despite the ribosome helicase, certain mRNA stem-loops stimulate programmed ribosomal frameshift by inhibiting translation elongation. Here, using mutagenesis, biochemical and single-molecule experiments, we examine whether high stability of three basepairs, which are unwound by the translating riboso...

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Literature Corpus work: 1b281353-01ed-5591-9b26-dce01ed4300f
DOI: 10.1101/2021.08.16.456581

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